FDA approves new class of non-opioid pain medication

A child kissing their father on the cheek

The U.S. Food and Drug Administration (FDA) recently approved a new prescription pain reliever for adults with moderate to severe acute pain. The drug—branded as Journavx®—is the first in a new class of pain meds that will soon be available nationwide.

“This is really exciting news because for the first time in more than 20 years, we’re developing a brand-new class of analgesics,” says Dr. Jason Smith, MD, an interventional pain physiatrist at Atlantic Health.

How does it work?

Dr. Smith explains this groundbreaking non-opioid medication does not affect the brain’s reward center the way opioids do. Instead, it targets selective pain pathways, blocking the sodium channels that stimulate pain.

What conditions does it treat?

This oral medication is currently FDA-approved solely for short-term pain management use. This includes postsurgical pain, trauma, and acute back pain or osteoarthritic injuries, depending on the severity.

Are there side effects?

Although some patients experience side effects, studies show most responses to Journavx® are relatively mild. Adverse reactions can include itching, rash, or muscle spasms, and may be more severe in patients who are sensitive to these issues.

Three existing classes of prescription pain relievers

Prescription-strength Tylenol® (acetaminophen) disrupts pain signals in the body, making it effective for mild to moderate pain. It lower fevers and relieves aches and pains. However, acetaminophen does not reduce inflammation in the body.
Non-steroid anti-inflammatory drugs (NSAIDs) treat mild to moderate pain by blocking certain enzymes (Cox-1 and Cox-2) and producing prostaglandins that decrease pain, inflammation, and swelling.
Opioids act on the brain’s reward centers. Although opioids are strong and effective, they come with a significant risk of addiction, which has fueled an epidemic of dependency and overdose.

“I describe the three classes of pain medications like a radio station,” says Dr. Smith. “Tylenol® turns down the volume. NSAIDS stop the broadcast altogether. Opioids block the broadcast and play music – songs you want to hear again and again.”

Ushering in a new class of pain relievers

According to Dr. Smith, opioids will always be an effective way to treat short-term pain. What’s needed is a safe long-term way to treat moderate to severe pain. This promising new drug class just might be the answer.

“For now, this new medication is being marketed for severe acute pain,” says Dr. Smith. “But at some point, I wouldn't be surprised if it’s extended to manage long-term pain, too. It’s got a lot of potential.”

Is it time to talk to your doctor?

Despite the drug’s limited availability and insurance coverage, Dr. Smith encourages patients to talk with their doctors about pain management options.

“Patients are already hearing about Journavx® and asking questions,” he says. “It’s important to talk with your health care provider about new advancements in health care.”

Find an Orthopedist

Published: April 30, 2025

Healthy LivingBlood work basics: What those tests actually meanUnderstand common blood tests and what your results mean with guidance from an Atlantic Health physician to help you stay on top of your health.

OrthopedicsInnovative tissue transplant surgery helps soccer player return to formYoung athlete returns to sports after knee injury with expert orthopedic care from Atlantic Health.

PregnancyGestational diabetes: Dispelling the mythsLearn the myths and facts about gestational diabetes, including risks, diagnosis, and how to manage blood sugar for a healthy pregnancy from an Atlantic Health expert.

Patient StoriesNo longer running on empty: Taking on a marathon after bariatric surgeryAfter weight loss surgery at Atlantic Health, a patient loses 110 pounds and embraces lasting lifestyle changes and improved health.

Healthy Living11 thyroid myths and facts: The truth behind thyroid diseaseAn Atlantic Health endocrinologist debunks common thyroid myths and shares facts on how to effectively treat hyperthyroidism and hypothyroidism.

Women's HealthWhat urine can reveal during your pregnancyPregnancy can change your urine in surprising ways. From color to smell to frequency, this Atlantic Health expert explains what’s normal—and what’s not.

Children's HealthMMR vaccine myths vs. facts: What parents should knowGet the facts about the MMR vaccine, including safety, effectiveness and common myths about measles, mumps and rubella.

Healthy Living5 ways to get vitamin D naturallyAn Atlantic Health expert explains why vitamin D matters—and how your body can produce more of this essential nutrient, naturally.

Press ReleaseAtlantic Health announces medical center leadership changesHighlighting the strength of its leadership team, Atlantic Health today announced the following updates to its senior executive structure.

PregnancyHigh blood pressure during pregnancy: what you need to knowPregnancy stresses a woman’s heart. In its most severe form, it is called preeclampsia, which is potentially life-threatening and can have lifelong cardiac implications for mother and baby.

Press ReleaseThree Atlantic Health medical centers earn top five-star rating from CMS Atlantic Health earns top Centers for Medicare and Medicaid Services (CMS) hospital ratings in 2026, with three medical centers achieving five stars and all six receiving four stars or higher.

Patient StoriesPlainfield man’s cosmetic procedure becomes a fight for survivalA vacation overseas became a life-threatening medical crisis for 29-year-old DD — but also an extraordinary story of survival, resilience and advanced care delivered by Atlantic Health.